Digoxin pharmacokinetics: role of renal failure in dosage regimen design.

  title={Digoxin pharmacokinetics: role of renal failure in dosage regimen design.},
  author={Jeffrey R. Koup and William J. Jusko and C M Elwood and Romesh K. Kohli},
  journal={Clinical pharmacology and therapeutics},
  volume={18 1},
Radioimmunoassayed serum concentration and urinary excretion data for digoxin from azotemic patients were characterized using a 2-compartment open model. Urinary excretion rates of digoxin as well as serum concentration data are needed to accurately characterize the disposition of the drug. Seven patients with renal failure showed highly variable steady-state volumes of distribution (V-ss-D equals 195 to 489 liters/1.73 m-minus2) and t1/2beta values (1.5 to 5.2 days). This variability is a… CONTINUE READING

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