Digoxin enhances the effect of antiepileptic drugs with different mechanism of action in the pentylenetetrazole-induced seizures in mice

@article{Tsyvunin2020DigoxinET,
  title={Digoxin enhances the effect of antiepileptic drugs with different mechanism of action in the pentylenetetrazole-induced seizures in mice},
  author={Vadim Tsyvunin and Sergiy Shtrygol’ and Diana Shtrygol’},
  journal={Epilepsy Research},
  year={2020},
  volume={167}
}

Digoxin potentiates the anticonvulsant effect of carbamazepine and lamotrigine against experimental seizures in mice

Digoxin can reduce the doses of carbamazepine and lamotrigine with a corresponding reduction in the risk of side effects without compromising treatment efficacy, and renders a marked anticonvulsant action on the model of pentylenetetrazole-induced seizures as well as on seizures induced by MES.

Low-dose digoxin enhances the anticonvulsive potential of carbamazepine and lamotrigine in chemo-induced seizures with different neurochemical mechanisms

It can be concluded that digoxin has a high potential as an adjuvant medicine in complex epilepsy treatment because it enhances the efficiency of low-dose traditional anticonvulsants carbamazepine and lamotrigine regardless of the pathogenesis of experimental paroxysms.

Low-Dose Digoxin is Associated with Anticonvulsant Effect Enhancement of Classical Antiepileptic Drugs in the Electro-Induced Seizures in Mice

It was found that low-dose digoxin potentiates the anticonvulsant effects of sodium valproate, topiramate and phenobarbital as well as modulates the effects of levetiracetam and clonazepam, showing a distinct pharmacological effect of their sub-effective doses and increasing their therapeutic potential even under incomplete seizure control – the equivalent of drug-resistant epilepsy.

SGLT-2 inhibitors as potential anticonvulsants: empagliflozin, but not dapagliflozin, renders a pronounced effect and potentiates the sodium valproate activity in pentylenetetrazole-induced seizures

Empagliflozin has a high potential as an adjuvant medicine in treating epilepsy, as it enhances the efficacy of the classic anticonvulsant sodium valproate without muscle relaxant side effects.

Interaction of surfactants with poloxamers 338 and its effect on some properties of cream base

The aim. Study of the interaction of surfactants with poloxamer 338 (P338) and the effect of P338 on the properties of cream bases. Materials and methods. Solutions of the surfactants and P338 as

Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures.

It was found that under the conditions of primary generalized seizures induced by picrotoxin, thiosemicarbazide, strychnine, and camphor, digoxin not only shows its own strong anticonvulsant activity but also significantly enhances the anticonVulsant potential of classical AEDs sodium valproate, levetiracetam, and topiramate.

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