Digoxin degradation in acidic dissolution medium.

  title={Digoxin degradation in acidic dissolution medium.},
  author={Takashi Sonobe and S Hasumi and Takashi Yoshino and Yoshikazu Kobayashi and Hiroaki Kawata and Tsuneji Nagai},
  journal={Journal of pharmaceutical sciences},
  volume={69 4},
The release of digoxin and its simultaneous conversion to digoxigenin bisdigitoxoside, digoxigenin monodigitoxoside, and digoxigenin in a USP dissolution test medium were followed by high-pressure liquid chromatography. Two products, Tablets A and B, were manufactured by solvent deposition and simple blending methods, respectively. Tablet A released digoxin… CONTINUE READING