Digoxin: Pharmacology and toxicology-A review.
@article{Patoka2020DigoxinPA, title={Digoxin: Pharmacology and toxicology-A review.}, author={Jiř{\'i} Pato{\vc}ka and Eugenie Nepovimova and Wenda Wu and Kamil Ku{\vc}a}, journal={Environmental toxicology and pharmacology}, year={2020}, volume={79}, pages={ 103400 } }
16 Citations
Benefit versus toxicity risk of digoxin in patients with COVID-19
- Medicine, BiologyEuropean journal of hospital pharmacy : science and practice
- 2021
Despite the potential benefits of digoxin in patients with COVID-19, special consideration should be given to patients receiving treatment with digoxin regarding the effect of CO VID-19 itself (disease stage, electrolyte disturbance, organ damage especially liver) and concomitant usage of COvid-19 medications in order to avoid digoxin toxicity.
Digoxin Holiday
- MedicineVidarbha Journal of Internal Medicine
- 2022
A summary of the evidence relating to the rationale behind using digoxin holiday and the therapeutic implications of digoxinholiday is provided.
Repurposing of digoxin in pain and inflammation: An evidence-based study.
- Biology, MedicineDrug development research
- 2022
The histopathological evaluation revealed that digoxin treatment attenuated the edema, neutrophil infiltration, and alveolar septal thickening in lung tissue, and highlight the newer insights towards repurposing digoxin as a new lead in the treatment of hyperalgesia, inflammation, and related disorders.
Synthesis and Biological Evaluation of Novel Bufalin Derivatives
- Biology, ChemistryInternational journal of molecular sciences
- 2022
The two bufalin derivatives synthesized exhibited biological activities similar to those of other CS in the tested experimental systems, but with reduced cytotoxicity, advocating their development as drugs for the treatment of heart failure and arrhythmias.
Low-dose digoxin enhances the anticonvulsive potential of carbamazepine and lamotrigine in chemo-induced seizures with different neurochemical mechanisms
- Medicine, BiologyScienceRise: Pharmaceutical Science
- 2021
It can be concluded that digoxin has a high potential as an adjuvant medicine in complex epilepsy treatment because it enhances the efficiency of low-dose traditional anticonvulsants carbamazepine and lamotrigine regardless of the pathogenesis of experimental paroxysms.
Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology
- Chemistry, BiologyFrontiers in Pharmacology
- 2022
With the toxicology of oleandrin being thoroughly reviewed, the development of safe clinical applications of oLEandrin may be possible given potential research strategies to decrease toxicity.
Predictive Factors for Recurrence of Serious Arrhythmias in Patients with Acute Digoxin Poisoning.
- MedicineCardiovascular toxicology
- 2021
Serum digoxin level had an excellent discriminatory power with the best sensitivity and specificity, followed by serum potassium level in both groups, and Logistic regression analysis showed that only serum digoxin and potassium levels were significant independent predictors of recurrent serious arrhythmias and temporary pacing.
Structural Insights into the Interactions of Digoxin and Na+/K+-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
- Biology, ChemistryMolecules
- 2021
Differentially, digoxigenin, the aglycon of digoxin, binds to HDAC and PI3K, but not FIH-1, IAP, Na+/K+-ATPase, and NF-κB, indicating that this compound may target tumor autophagy and metabolism to mediate its antitumor propensity.
Current state and future perspective of cardiovascular medicines derived from natural products.
- BiologyPharmacology & therapeutics
- 2020
References
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Digoxin: clinical highlights: a review of digoxin and its use in contemporary medicine.
- MedicineCritical pathways in cardiology
- 2011
Digoxin dosing based on patient-specific factors such as age, lean body weight, and renal function will allow practitioners to minimize drug toxicity while maintaining clinical efficacy.
[Severe digoxin poisoning a case study].
- MedicinePrzeglad lekarski
- 2011
A 45-years-old patient who was hospitalized following the ingestion with suicidal intent of 100 0.25 mg tablets of digoxin, typical symptoms of severe poisoning were observed: from gastric symptoms (severe nausea, vomiting) to numerous severe arrhythmias and conduction disturbances.
Digoxin as a glycosylated steroid-like therapeutic drug: Recent advances in the clinical pharmacology and bioassays of pharmaceutical compounds.
- Biology, MedicineBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2020
2. Report of a Suicidal Digoxin Intoxication: A Case Report
- MedicineMedicine, science, and the law
- 2002
This report describes an overdose fatality involving digoxin in a suicidal 82-year-old man, in whom measurement of serum digoxin concentration is available, and reveals digoxin concentrations within 12.2–13.2 ng/ml in the blood.
Massive digoxin intoxication. Report of a case with serum digoxin level correlation.
- MedicineActa cardiologica
- 1975
A patient who took an overdose of 15 mg of digoxin in a suicidal attempt developed several cardiac arrhythmias like atrial fibrillation, atrial flutter, sino-atrial block, and atrio-ventricular block 3 degree and ventricular extrasystoles.
Pharmacokinetic Interactions with Digoxin
- Medicine, BiologyClinical pharmacokinetics
- 1988
Cardiac patients receiving digoxin therapy are particularly prone to interactions with commonly co-administered medications such as the antiarrhythmics quinidine and amiodarone, the calcium channel blockers verapamil and nifedipine, and possibly some vasodilating agents.
Acute digoxin overdose: use of digoxin-specific antibody fragments.
- MedicineThe American journal of emergency medicine
- 1988
[Suicidal intoxication with digoxin--still actual problem in clinical toxicology--case report].
- MedicinePrzeglad lekarski
- 2012
Temporary invasive cardiac pacing with single chamber ventricular pacer was performed for treatment of the life-threatening rhythm and conduction disturbances that revealed within few hours after admission.
Contemporary Controversies in Digoxin Use in Systolic Heart Failure
- MedicineCurrent Heart Failure Reports
- 2016
Recent data on the use of digoxin in systolic heart failure is summarized and some of the controversies regarding the role ofdigoxin in the modern era of heart failure treatment are addressed.