Digoxin: Pharmacology and toxicology-A review.

@article{Patoka2020DigoxinPA,
  title={Digoxin: Pharmacology and toxicology-A review.},
  author={Jiř{\'i} Pato{\vc}ka and Eugenie Nepovimova and Wenda Wu and Kamil Ku{\vc}a},
  journal={Environmental toxicology and pharmacology},
  year={2020},
  volume={79},
  pages={
          103400
        }
}
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References

SHOWING 1-10 OF 118 REFERENCES
Digoxin: clinical highlights: a review of digoxin and its use in contemporary medicine.
TLDR
Digoxin dosing based on patient-specific factors such as age, lean body weight, and renal function will allow practitioners to minimize drug toxicity while maintaining clinical efficacy.
[Severe digoxin poisoning a case study].
TLDR
A 45-years-old patient who was hospitalized following the ingestion with suicidal intent of 100 0.25 mg tablets of digoxin, typical symptoms of severe poisoning were observed: from gastric symptoms (severe nausea, vomiting) to numerous severe arrhythmias and conduction disturbances.
2. Report of a Suicidal Digoxin Intoxication: A Case Report
TLDR
This report describes an overdose fatality involving digoxin in a suicidal 82-year-old man, in whom measurement of serum digoxin concentration is available, and reveals digoxin concentrations within 12.2–13.2 ng/ml in the blood.
Massive digoxin intoxication. Report of a case with serum digoxin level correlation.
TLDR
A patient who took an overdose of 15 mg of digoxin in a suicidal attempt developed several cardiac arrhythmias like atrial fibrillation, atrial flutter, sino-atrial block, and atrio-ventricular block 3 degree and ventricular extrasystoles.
Pharmacokinetic Interactions with Digoxin
TLDR
Cardiac patients receiving digoxin therapy are particularly prone to interactions with commonly co-administered medications such as the antiarrhythmics quinidine and amiodarone, the calcium channel blockers verapamil and nifedipine, and possibly some vasodilating agents.
Acute digoxin overdose: use of digoxin-specific antibody fragments.
[Suicidal intoxication with digoxin--still actual problem in clinical toxicology--case report].
TLDR
Temporary invasive cardiac pacing with single chamber ventricular pacer was performed for treatment of the life-threatening rhythm and conduction disturbances that revealed within few hours after admission.
Contemporary Controversies in Digoxin Use in Systolic Heart Failure
TLDR
Recent data on the use of digoxin in systolic heart failure is summarized and some of the controversies regarding the role ofdigoxin in the modern era of heart failure treatment are addressed.
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