Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel

  title={Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel},
  author={Juan S Yakisich and Neelam Azad and Rajkumar Venkatadri and Yogesh M Kulkarni and Clayton A Wright and Vivek Kaushik and George Augustine O'Doherty and Anand Krishnan V Iyer},
  journal={Oncology Reports},
  pages={878 - 886}
Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single agents. Therefore, there is an urgent need for new anticancer drugs or drug combination regimens that possess increased activity against all cellular subtypes found within the tumor. In this study, we evaluated the in vitro antiproliferative… 

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