Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

@inproceedings{Martin2017DigitallyBM,
  title={Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis},
  author={Constance J. Martin and Anthony M. Cadena and Vivian W. Y. Leung and Philana Ling Lin and Pauline Maiello and Nathan S. Hicks and Michael R Chase and JoAnne L. Flynn and Sarah M Fortune},
  booktitle={mBio},
  year={2017}
}
Infection with Mycobacterium tuberculosis causes a spectrum of outcomes; the majority of individuals contain but do not eliminate the infection, while a small subset present with primary active tuberculosis (TB) disease. This variability in infection outcomes is recapitulated at the granuloma level within each host, such that some sites of infection can be fully cleared while others progress. Understanding the spectrum of TB outcomes requires new tools to deconstruct the mechanisms underlying… CONTINUE READING
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