Digitalislike circulating factor in hypertension: potential messenger between salt balance and intracellular sodium.

@article{Haddy1990DigitalislikeCF,
  title={Digitalislike circulating factor in hypertension: potential messenger between salt balance and intracellular sodium.},
  author={Francis J. Haddy},
  journal={Cardiovascular drugs and therapy},
  year={1990},
  volume={4 Suppl 2},
  pages={343-9}
}
Sodium chloride has no clearly established local direct action on blood vessels to produce constriction; on the contrary, it has an immediate local indirect action via osmolality, which produces vasodilation. Thus in order to explain salt-induced hypertension, a delayed remote indirect vasoconstrictor action must be postulated. This indirect vasoconstrictor action is apparently the result of volume expansion. Acute volume expansion imparts three physiologic properties to the plasma; these are… CONTINUE READING
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