Digitalis tolerance and effect of acety-strophanthidin upon serum potassium of dogs with acidosis and uremia.

  title={Digitalis tolerance and effect of acety-strophanthidin upon serum potassium of dogs with acidosis and uremia.},
  author={H H Schafer and A. Calhoun Witham and John Burns},
  journal={American heart journal},
14 Citations

Increased Digitalis Tolerance in Uremic Patients

A prospective study was undertaken to determine the incidence of digitalis toxicity in patients with an elevated plasma digoxin in relation to the plasma creatinine and accumulated some evidence that digitalis tolerance is in fact increased in uremic patients in relationto the plasma concentration.

The influence of reduced serum potassium level on the toxicity of some cardenolides in guinea pigs

SummaryRecent experiments on the pharmacological properties of the semisynthetic cardiotonic steroid strophanthidin-3-bromoacetate (SBA) have challenged the well-known potassium digitalis antagonism

Loading dose of digoxin in renal failure.

The average apparent volume of distribution of digoxin in dialysis dependent patients was found to be reduced by about one third compared with that reported for individuals with normal renal function, but there was great variation.


There was no statistically significant difference between the incidence of postperfusion electrocardiographic arrhythmias in patients who had been digitalized prior to perfusion and in patientswho had not received digitalis, and the application of this information to the administration of digitalis to patients undergoing open heart surgery is discussed.

Recognition and therapy of digitalis toxicity.



Myocardial transfer of sodium and potassium: effect of acetyl strophanthidin in normal dogs.

Although the hemodynamic events attending low-output congestive heart failure have been well defined, the biochemical changes in the myocardium responsible for these events and the response to

Digitalis antagonism. Part II.

In the first part of this paper (A.M.A. Arch. Int. Med . 101:849 [May] 1958), an attempt was made to describe the graded toxic response to digitalis as a phenomenon which exhibits varying degrees of

Electrocardiographic Alterations Produced by a Decrease in Plasma pH, Bicarbonate and Sodium as Compared with those Produced by an Increase in Potassium

The effects of a decrease in plasma pH, bicarbonate and sodium on the electrocardiographic pattern are compared with those produced by elevation of serum potassium and lithium in the dog and are correlated with those found in isolated nerve and muscle preparations.

Current concepts in digitalis therapy.

The use of digitalis marks the beginning of the modern era of cardiac therapy and the purified derivatives, the cardiac glycosides, continue as the most effective medicinal herbs in the world.

Action of digitalis glucosides on isolated frog heart.