Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome.

@article{Iczkowski2011DigitalQO,
  title={Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome.},
  author={Kenneth A. Iczkowski and Kathleen C. Torkko and Gregory R Kotnis and R. Storey Wilson and Wei Huang and Thomas M. Wheeler and Andrea M. Abeyta and Francisco G. La Rosa and Shelly Cook and Priya N. Werahera and M. Scott Lucia},
  journal={American journal of clinical pathology},
  year={2011},
  volume={136 1},
  pages={
          98-107
        }
}
Proper grading of the cribriform prostate cancer pattern has not previously been supported by outcome-based evidence. Among 153 men who underwent radical prostatectomy, 76 with prostate-specific antigen (PSA) failure (≥0.2 ng/mL [0.2 μg/L]) were matched to 77 without failure. Frequencies of high-grade patterns included fused small acini, 83.7%; papillary, 52.3%; large cribriform, 37.9%; small (≤12 lumens) cribriform, 17.0%; and individual cells, 22.9%. A cribriform pattern was present in 61… 
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