Digital karyotyping reveals frequent inactivation of the dystrophin/DMD gene in malignant melanoma.

@article{Krner2007DigitalKR,
  title={Digital karyotyping reveals frequent inactivation of the dystrophin/DMD gene in malignant melanoma.},
  author={Henrike K{\"o}rner and Alexey Epanchintsev and Carola Berking and Beatrice Schuler-Thurner and Michael R. Speicher and Antje Menssen and Heiko Hermeking},
  journal={Cell cycle},
  year={2007},
  volume={6 2},
  pages={189-98}
}
Malignant melanoma is still poorly understood at the genomic level. Recently, a new technique for the high-resolution analysis of copy number changes named digital karyotyping was introduced. This approach is derived from SAGE (serial analysis of gene expression) and allows the detection of genomic amplifications and deletions, which are indicative of oncogenes and tumor suppressor genes. Four human melanoma cell lines were subjected to analysis by digital karyotyping. 828,780 genomic tags were… CONTINUE READING