Digital gene expression profiling of primary acute lymphoblastic leukemia cells

@inproceedings{Nordlund2012DigitalGE,
  title={Digital gene expression profiling of primary acute lymphoblastic leukemia cells},
  author={Jessica Nordlund and Anna Kiialainen and Olof Karlberg and E C Berglund and Hanna G{\"o}ransson-Kultima and M S\onderk{\ae}r and K L Nielsen and M G Gustafsson and Mikael Behrendtz and Erik Forestier and Markus Perkki{\"o} and Stefan S{\"o}derh{\"a}ll and Gudmar L{\"o}nnerholm and A-C Syv{\"a}nen},
  booktitle={Leukemia},
  year={2012}
}
We determined the genome-wide digital gene expression (DGE) profiles of primary acute lymphoblastic leukemia (ALL) cells from 21 patients taking advantage of ‘second-generation’ sequencing technology. Patients included in this study represent four cytogenetically distinct subtypes of B-cell precursor (BCP) ALL and T-cell lineage ALL (T-ALL). The robustness of DGE combined with supervised classification by nearest shrunken centroids (NSC) was validated experimentally and by comparison with… CONTINUE READING
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