Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?

  title={Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?},
  author={B. Zimmermann and S. Grill and W. Holzgreve and X. Zhong and L. Jackson and S. Hahn},
  journal={Prenatal Diagnosis},
  • B. Zimmermann, S. Grill, +3 authors S. Hahn
  • Published 2008
  • Medicine
  • Prenatal Diagnosis
  • Recent reports have indicated that digital PCR may be useful for the noninvasive detection of fetal aneuploidies by the analysis of cell‐free DNA and RNA in maternal plasma or serum. In this review we provide an insight into the underlying technology and its previous application in the determination of the allelic frequencies of oncogenic alterations in cancer specimens. We also provide an indication of how this new technology may prove useful for the detection of fetal aneuploidies and single… CONTINUE READING
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