Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization

  title={Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization},
  author={Mih{\^a}ly Arat{\^o} and Ede Frecska and Cindy Beck and Mary An and H. G. Kiss},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • M. Aratô, E. Frecska, H. Kiss
  • Published 31 January 2004
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Sex/gender differences in the brain and cognition in schizophrenia
Family History Correlates of Digit Ratio Abnormalities in Schizophrenia
Overall, in patients, reversal of expected “directionality” in digit ratio was observed in this study with greater left 2D: 4D in male patients having a family history of schizophrenia being a novel finding.
Reversal of normal cerebral sexual dimorphism in schizophrenia: evidence and speculations.
  • A. Mendrek
  • Psychology, Biology
    Medical hypotheses
  • 2007
The 2D:4D ratio of the hand and schizotypal personality traits in schizophrenia patients and healthy control persons.
Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia
Do clinical features relate to theory of mind, empathy and 2D:4D in schizophrenia?
It was found that negative symptoms but not male-biased 2D:4D ratio were significantly associated with impaired RMET performance and negative dimension is negatively related to the severity of deficits in social cognition in schizophrenia.
Schizotypy and altered digit ratios: A second look
Association between the 2D:4D ratio and schizophrenia
The findings support the hypothesis that there are abnormal cerebral conditions in schizophrenia patients, and the 2D:4D ratio was sexually dimorphic, with a larger value in women than in men.


The neurodevelopmental basis of sex differences in schizophrenia.
Much of the contemporary confusion about schizophrenia results from the conflation of two separate disorders, one commonest in young males and the other in older females.
Sex differences in schizophrenia, a review of the literature.
  • A. Leung, P. Chue
  • Psychology, Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 2000
This review supports the presence of significant differences between schizophrenic males and females arising from the interplay of sex hormones, neurodevelopmental and psychosocial sex differences.
Child Age and Planum Temporale Asymmetry
For the age range studied, the results suggest that functional differentiation follows a structural asymmetry that is already "preset," with girls displaying a stronger leftward PT asymmetry, independently of age.
Cerebral lateralization. Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research.
The hypothesis is that slowed growth within certain zones of the left hemisphere is likely to result in enlargement of other cortical regions, in particular, the homologous contralateral area, but also adjacent unfaffected regions.
Brain maturational processes and delayed onset in schizophrenia
It is proposed that the schizophrenic syndrome may result from early brain adversity and late maturational processes of brain development interacting with adverse humoral, biochemical, and psychosocial factors during adolescence and early adulthood.
Finger-length ratios and sexual orientation
The androgen-sensitive pattern of finger lengths is examined, and there is evidence that homosexual women are exposed to more prenatal androgen than heterosexual women are, and men with more than one older brother, who are more likely than first-born males to be homosexual in adulthood, are exposure to more pregnancies than eldest sons.
Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients.
Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matterVolume reduction, suggesting that such abnormalities are present at first episode and are specific to schizophrenia.
Second to fourth digit ratio and male ability in sport: implications for sexual selection in humans.
  • J. Manning, R. Taylor
  • Education
    Evolution and human behavior : official journal of the Human Behavior and Evolution Society
  • 2001