Digestion of proteoglycans in porcine pancreatic elastase-induced emphysema in rats.

  title={Digestion of proteoglycans in porcine pancreatic elastase-induced emphysema in rats.},
  author={Chris H A van de Lest and Elly M. M. Versteeg and Jacques H. Veerkamp and Toin H van Kuppevelt},
  journal={The European respiratory journal},
  volume={8 2},
Pulmonary emphysema was induced in rats by a single intratracheal instillation of pancreatic elastase. The short-term effects of elastase instillation on basement membrane components were evaluated using immunohistochemical and biochemical methods. Lung alveoli showed a decrease in heparan sulphate proteoglycan content (especially of its heparan sulphate chains) 3 h to 7 days after induction. Type IV collagen, laminin and fibronectin were not affected. The glycosaminoglycan content of the lung… CONTINUE READING
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