Difluoromethylornithine inhibits crypt fission


Crypt fission is a physiologic mechanism of crypt reproduction. It increases in pathophysiologic situations where intestinal regeneration is required (e.g., radiation injury). Polyamine metabolism is important in the regulation of intestinal growth and recovery from injury in response to a variety of stimuli. Our aim was to determine whether inhibition of… (More)
DOI: 10.1016/S1091-255X(99)80090-0


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