Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.

@article{Kadmon1982DifluoromethylornithineEO,
  title={Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.},
  author={Dov Kadmon and Warren DeWayne Heston and David W. Lazan and William R. Fair},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1982},
  volume={23 11},
  pages={
          998-1002
        }
}
We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine… CONTINUE READING