Diflunisal inhibits prestin by chloride-dependent mechanism

@inproceedings{Duret2017DiflunisalIP,
  title={Diflunisal inhibits prestin by chloride-dependent mechanism},
  author={Guillaume Duret and Fred A Pereira and Robert M. Raphael},
  booktitle={PloS one},
  year={2017}
}
The motor protein prestin is a member of the SLC26 family of anion antiporters and is essential to the electromotility of cochlear outer hair cells and for hearing. The only direct inhibitor of electromotility and the associated charge transfer is salicylate, possibly through direct interaction with an anion-binding site on prestin. In a screen to identify other inhibitors of prestin activity, we explored the effect of the non-steroid anti-inflammatory drug diflunisal, which is a derivative of… CONTINUE READING
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