Diffusional transport of macromolecules in developing nerve processes.

  title={Diffusional transport of macromolecules in developing nerve processes.},
  author={Sergei V Popov and Mu ming Poo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={12 1},
Passive transport of macromolecules in growing nerve processes was analyzed quantitatively by measuring the rate of diffusion of fluorescently labeled molecules injected into the soma of cultured Xenopus neurons. We found that the diffusion of globular proteins in the neurite's cytoplasm was about five times slower than that in aqueous solution, a rate considerably higher than those inferred from previous studies on cultured non-neuronal cells. The dependence of the diffusion coefficient, D, on… CONTINUE READING

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