Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy

@inproceedings{Papaevangelou2015DiffusionweightedMF,
  title={Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy},
  author={Efthymia Papaevangelou and Gilberto Serrano de Almeida and Yann Jamin and Simon P Robinson and Nandita M deSouza},
  booktitle={British Journal of Cancer},
  year={2015}
}
Background:Non-invasive serial imaging is desirable to detect processes such as necrotic and apoptotic cell death in cancer patients undergoing treatment. This study investigated the use of diffusion-weighted (DW-) magnetic resonance imaging (MRI) for imaging cell death induced by either a cytotoxic drug (irinotecan), or the apoptosis-inducing agent birinapant, in human tumour xenografts in vivo.Methods:Nude mice bearing human SW620 colon carcinoma xenografts were treated with vehicle… CONTINUE READING
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