Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment.

@article{Amlien2014DiffusionTI,
  title={Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment.},
  author={Inge K. Amlien and Anders M. Fjell},
  journal={Neuroscience},
  year={2014},
  volume={276},
  pages={206-15}
}
Alzheimer's disease (AD) has traditionally been regarded as a disease of the gray matter (GM). However, the advent of diffusion tensor imaging (DTI) has contributed to new knowledge about how changes in white matter (WM) microstructure in vivo may be directly related to the pathophysiology of AD. It is now evident that WM is heavily affected in AD, even at early stages. Still, our knowledge about WM degeneration in AD is poor compared to what we know about GM atrophy. For instance, it has not… CONTINUE READING
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