Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2.

  title={Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2.},
  author={Maria Luisa Mandelli and Tiziana De Simone and Ludovico Minati and Maria Grazia Bruzzone and Caterina Mariotti and Roberto Fancellu and Mario Savoiardo and Marina Grisoli},
  journal={AJNR. American journal of neuroradiology},
  volume={28 10},
BACKGROUND AND PURPOSE Structural MR imaging does not enable reliable differentiation of spinocerebellar ataxia (SCA) types 1 and 2 (SCA1 and SCA2), and imaging may be normal during the first years after the onset of symptoms. We aimed at determining whether measurements of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) may enable their differentiation. MATERIALS AND METHODS We enrolled 14 patients with SCA1, 11 with SCA2, and 9 age-matched controls. Diffusion tensor… CONTINUE READING


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