Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS.

@article{Graham2004DiffusionTI,
  title={Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS.},
  author={Jacqueline M Graham and Nikolaos Papadakis and Julie Evans and Elysa Widjaja and Charles Anthony Jozef Romanowski and Martyn N. J. Paley and Lauren I. Wallis and Iain D. Wilkinson and Pamela J Shaw and Paul D. Griffiths},
  journal={Neurology},
  year={2004},
  volume={63 11},
  pages={2111-9}
}
BACKGROUND High angular resolution diffusion tensor imaging (HARD) is an MRI technique that exploits the mobility of water molecules to yield maps of structural order and directionality of white matter tracts with greater precision than six-direction diffusion tensor imaging (DTI) schemes. OBJECTIVE To assess whether HARD is more sensitive than conventional MRI or neurologic assessment in detecting the upper motor neuron (UMN) pathology of patients with ALS. METHODS Twenty-five patients… CONTINUE READING
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