Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability.

@article{Thivard2007DiffusionTI,
  title={Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability.},
  author={Lionel Thivard and P-F Pradat and St{\'e}phane Leh{\'e}ricy and Lucette Lacomblez and Didier Dormont and J Chiras and Habib Benali and Vincent Meininger},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2007},
  volume={78 8},
  pages={889-92}
}
The aim of this study was to investigate the extent of cortical and subcortical lesions in amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor imaging (DTI) and voxel based morphometry (VBM). We included 15 patients with definite or probable ALS and 25 healthy volunteers. Patients were assessed using the revised ALS Functional Rating Scale (ALSFRS-R). In patients, reduced fractional anisotropy was found in bilateral corticospinal tracts, the left insula… CONTINUE READING
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