Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.

@article{Bradbury2016DiffusionTI,
  title={Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.},
  author={Allison M. Bradbury and David August Peterson and Charles Herman Vite and Steven D Chen and Norman Matthew Ellinwood and James M. Provenzale},
  journal={The neuroradiology journal},
  year={2016},
  volume={29 6},
  pages={
          417-424
        }
}
PURPOSE The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. METHODS An 11-week-old Krabbe dog was euthanized after disease progression. The brain was removed… CONTINUE READING
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