Diffusion tensor MR imaging of the human brain.

@article{Pierpaoli1996DiffusionTM,
  title={Diffusion tensor MR imaging of the human brain.},
  author={Carlo Pierpaoli and Peter Jezzard and Peter J. Basser and Alan S. Barnett and Giovanni di Chiro},
  journal={Radiology},
  year={1996},
  volume={201 3},
  pages={
          637-48
        }
}
PURPOSE To assess intrinsic properties of water diffusion in normal human brain by using quantitative parameters derived from the diffusion tensor, D, which are insensitive to patient orientation. MATERIALS AND METHODS Maps of the principal diffusivities of D, of Trace(D), and of diffusion anisotropy indices were calculated in eight healthy adults from 31 multisection, interleaved echo-planar diffusion-weighted images acquired in about 25 minutes. RESULTS No statistically significant… 

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References

SHOWING 1-10 OF 50 REFERENCES
In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres.
TLDR
In cerebral gliomas ADC and IDA determinations provide information not available from routine MR imaging and allow distinction between normal white matter, areas of necrosis or cyst formation, regions of edema, and solid enhancing tumor.
Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system.
The diffusion behavior of intracranial water in the cat brain and spine was examined with the use of diffusion-weighted magnetic resonance (MR) imaging, in which the direction of the
Diffusional anisotropy of the human brain assessed with diffusion-weighted MR: relation with normal brain development and aging.
TLDR
Diffusion-weighted images demonstrated that the myelination process starts earlier in the occipital lobe than in the frontal lobe, and the changes of diffusional anisotropy in white matter are completed within 6 months after birth.
Toward a quantitative assessment of diffusion anisotropy
TLDR
New indices calculated from the entire diffusion tensor are rotationally invariant (RI) and show that anisotropy is highly variable in different white matter regions depending on the degree of coherence of fiber tract directions.
Adult and neonatal human brain: diffusional anisotropy and myelination with diffusion-weighted MR imaging.
TLDR
In neonates, diffusional anisotropy of white matter, in which no myelination was shown on T1- and T2-weighted images, was weak, and was more distinct after brain maturation, as observed in adult white matter.
MR diffusion tensor spectroscopy and imaging.
Diffusion Weighting by the Trace of the Diffusion Tensor within a Single Scan
TLDR
A family of imaging pulse sequences is presented in which the signal intensity is weighted by the trace of the diffusion tensor in a single scan to provide reliable diffusion constants in both homogeneous and inhomogeneous magnetic fields.
MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic, and pathologic considerations.
TLDR
Imaging of ARD affords a fascinating conjunction between the microscopic movement of water, the properties of myelinated white matter fibres, gross anatomy of the brain, and changes of the diffusion of water in disease.
Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study.
TLDR
It is found that the dependence of the diffusion coefficient on the diffusion time does not support the model of water restriction by impenetrable barriers, and results imply that water diffuses with a measurable rate across myelin fibers.
Navigated Diffusion Imaging of Normal and Ischemic Human Brain
TLDR
A modification of this technique is introduced, in which the phase correction step is performed in the frequency domain (i.e., after the readout Fourier transform), which significantly improves the robustness of the navigator echo approach and, when combined with cardiac gating, allows diagnostic quality diffusion‐weighted images of the brain to be routinely obtained on standard clinical scanner hardware.
...
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