Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction.

@article{Bisegna2008DiffusionOT,
  title={Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction.},
  author={Paolo Bisegna and Giovanni Paolo Caruso and Daniele Andreucci and Lixin Shen and Vsevolod V. Gurevich and Heidi E. Hamm and Emmanuele DiBenedetto},
  journal={Biophysical journal},
  year={2008},
  volume={94 9},
  pages={3363-83}
}
The single photon response in vertebrate phototransduction is highly reproducible despite a number of random components of the activation cascade, including the random activation site, the random walk of an activated receptor, and its quenching in a random number of steps. Here we use a previously generated and tested spatiotemporal mathematical and computational model to identify possible mechanisms of variability reduction. The model permits one to separate the process into modules, and to… CONTINUE READING