Diffusion of small molecular weight drugs in radiation-crosslinked poly ( ethylene oxide ) hydrogels

@inproceedings{Stringer2002DiffusionOS,
  title={Diffusion of small molecular weight drugs in radiation-crosslinked poly ( ethylene oxide ) hydrogels},
  author={Linda Stringer and Nikolaos A. Peppas},
  year={2002}
}
Poly(ethylene oxide) (PEO) hydrogels were formed by crosslinking of aqueous PEO solutions of IVI = 35 000, 900 000 and 5 000 000 in concentrations of 5-50% using T-irradiation with 3-10 Mrad. The hydrogels were characterized by equilibrium swelling experiments. The average interjunction molecular weight, 1VI c, varied from 3500 to 32 000, whereas the mesh size, ~:, varied from 120 to 550 ,~. The mesh size decreased with increased polymer molecular weight and solution concentration. Theophylline… CONTINUE READING
15 Citations
11 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Peppas, Preparation and characterization of pH-sensitive interpenetrating networks of poly(vinyl alcohol) and poly(acrylic acid)

  • N.A.L. Gudeman
  • J. Polym. Sci. Polym. Chem
  • 1995
2 Excerpts

Preparation and Structure of Radiation Crosslinked Poly(ethylene oxide) Hydrogel Membranes

  • J. L. Swiger now J.L. Stringer
  • 1995
2 Excerpts

Environmentally responsive polymers for membrane processes

  • L. Gudeman
  • MS thesis. Purdue University,
  • 1994
1 Excerpt

Solute Diffusion in Swollen Membranes., IX. Scaling Laws for Solute Diffusion in Gels

  • S. R. Lustig, N. A. Peppas
  • J. Appl. Polym. Sci
  • 1988
7 Excerpts

Hydrogels in Medicine and Pharmacy. Volume 1: Fundamentals

  • N. A. Peppas
  • CRC Press, Inc. Boca Raton. FL
  • 1986
6 Excerpts

On the kinetics of polymer degradation in solution, 9. Pulse radiolysis of poly(ethylene oxide)

  • U. Grollman, W. Schnabel
  • Makromol. Chem
  • 1980
3 Excerpts

Poly(vinyl alcohol) hydrogels: Reinforcement of radiation-crosslinked networks by crystallization

  • N. A. Peppas, E. W. Merrill
  • J. Polym. Sci. Polym. Chem
  • 1976
2 Excerpts

Preparation and characterization of pH - sensitive interpenetrating networks of poly ( vinyl alcohol ) and poly ( acrylic acid )

  • L. Gudeman, N. A. Peppas
  • J . Polym . Sci . Polym . Chem .
  • 1973

Similar Papers

Loading similar papers…