Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features.

@article{Giannola2007DiffusionON,
  title={Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features.},
  author={Libero Italo Giannola and Viviana de Caro and Giulia Giandalia and Maria Gabriella Siragusa and Giuseppina Campisi and Ada Maria Florena and Tomasz Ciach},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={65 2},
  pages={238-46}
}
In transbuccal absorption a major limitation could be the low permeability of the mucosa which implies low drug bioavailability. The ability of naltrexone hydrochloride (NLX) to penetrate a resembling histologically human buccal mucosa was assessed and the occurrence of any histomorphological changes observed. We used reconstituted human oral (RHO) non-keratinised epithelium as mucosal section and a Transwell diffusion cells system as bicompartmental model. Buccal permeation was expressed in… CONTINUE READING

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