Diffusion of macromolecules in model oral biofilms.

@article{Takenaka2009DiffusionOM,
  title={Diffusion of macromolecules in model oral biofilms.},
  author={Shoji Takenaka and Betsey Pitts and Harsh M. Trivedi and Philip S Stewart},
  journal={Applied and environmental microbiology},
  year={2009},
  volume={75 6},
  pages={1750-3}
}
The diffusive penetration of fluorescently tagged macromolecular solutes into model oral biofilms was visualized by time-lapse microscopy. All of the solutes tested, including dextrans, proteases, green fluorescent protein, and immunoglobulin G, accessed the interior of cell clusters 100 to 200 microm in diameter within 3 min or less.