Diffusion of macromolecule through retina after experimental branch retinal vein occlusion and estimate of intraretinal barrier.

@article{Tao2007DiffusionOM,
  title={Diffusion of macromolecule through retina after experimental branch retinal vein occlusion and estimate of intraretinal barrier.},
  author={Yong Tao and Xiao Li and Y. I. Jiang and Xia-bing Bai and Bi-dong Wu and Jian-qiang Dong},
  journal={Current drug metabolism},
  year={2007},
  volume={8 2},
  pages={151-6}
}
The disposition and diffusion knowledge of intravitreally injected macromolecule drugs through retina in pathological condition is crucial but the related studies are absent. Retinal edema is a common pathological change of fundus diseases and retinal vein occlusion (RVO) pig model were established to emulate it. FITC-dextrans of various molecular weights were dissolved in RPMI-1640 solutions and the rate of transretinal diffusion was determined with a spectrophotometer. Theoretical maximum… CONTINUE READING

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