Diffusion of macrolide antibiotics through the outer membrane of Moraxella catarrhalis

@article{Tsujimoto1999DiffusionOM,
  title={Diffusion of macrolide antibiotics through the outer membrane of Moraxella catarrhalis},
  author={Hideto Tsujimoto and Naomasa Gotoh and Takeshi Nishino},
  journal={Journal of Infection and Chemotherapy},
  year={1999},
  volume={5},
  pages={196-200}
}
We reported previously that the high susceptibility of Moraxella catarrhalis to macrolide antibiotics and other hydrophobic antimicrobial agents was related to the hydrophobicity of the cell surface. Electrophoretic analysis of lipopolysaccharide (LPS) extracted from M. catarrhalis revealed a deep rough-type profile similar to that of an LPS Re type mutant of Salmonella typhimurium, which also exhibits high susceptibility to macrolides. Moreover, treatment of 32P-labeled cells of M. catarrhalis… Expand
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