Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid

@article{Babi2012DiffusionOD,
  title={Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid},
  author={Marija M. Babi{\'c} and Slobodanka Jova{\vs}evi{\'c} and M Filipovic and Simonida Tomic Lj.},
  journal={Hemijska Industrija},
  year={2012},
  volume={66},
  pages={823-829}
}
The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly(2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/itaconic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel… 
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References

SHOWING 1-10 OF 27 REFERENCES
Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
TLDR
The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity, so these materials have potential as drug carriers or biological glue and sealants.
Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
TLDR
The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels.
Synthesis and hydration properties of pH-sensitive p(HEMA)-based hydrogels containing 3-(trimethoxysilyl)propyl methacrylate.
TLDR
The reversible pH-dependent swelling observed in these studies, along with the control of cross-link density afforded by the PMA component, endows these biocompatible materials with potential for use in pH-controlled drug delivery of more hydrophobic drugs and present new compositions for in vitro and in vivoBiocompatibility studies.
Preparation and characterization of infection-resistant antibiotics-releasing hydrogels rods of poly[hydroxyethyl methacrylate-co-(poly(ethylene glycol)-methacrylate]: biomedical application in a novel rabbit penile prosthesis model.
TLDR
Three different antibiotic loaded penile prosthesis in the rod form were concluded to be as effective as parenteral antibiotics applications.
Polymerization of oligo(ethylene glycol) (meth)acrylates: Toward new generations of smart biocompatible materials
  • J. Lutz
  • Materials Science, Biology
  • 2008
TLDR
Non linear PEG analogues can be either insoluble in water, readily soluble up to 100 °C, or thermoresponsive, and can be used for building a wide variety of modern materials such as biosensors, artificial tissues, smart gels for chromatography, and drug carriers.
Poly(ethylene glycol)-containing hydrogels in drug delivery.
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