Diffusion modeling of percutaneous absorption kinetics: 2. Finite vehicle volume and solvent deposited solids.

@article{Anissimov2001DiffusionMO,
  title={Diffusion modeling of percutaneous absorption kinetics: 2. Finite vehicle volume and solvent deposited solids.},
  author={Yuri G. Anissimov and Morton S. Roberts},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 4},
  pages={504-20}
}
The diffusion model for percutaneous absorption is developed for the specific case of delivery to the skin being limited by the application of a finite amount of solute. Two cases are considered; in the first, there is an application of a finite donor (vehicle) volume, and in the second, there are solvent-deposited solids and a thin vehicle with a high partition coefficient. In both cases, the potential effect of an interfacial resistance at the stratum corneum surface is also considered. As in… CONTINUE READING

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