Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.

@article{Berg1981DiffusiondrivenMO,
  title={Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.},
  author={Otto G. Berg and Robert B. Winter and Peter H. von Hippel},
  journal={Biochemistry},
  year={1981},
  volume={20 24},
  pages={
          6929-48
        }
}
Genome regulatory proteins (e.g., repressors or polymerases) that function by binding to specific chromosomal target base pair sequences (e.g., operators or promoters) can appear to arrive at their targets at faster than diffusion-controlled rates. These proteins also exhibit appreciable affinity for nonspecific DNA, and thus this apparently facilitated binding rate must be interpreted in terms of a two-step binding mechanism. The first step involves free diffusion to any nonspecific binding… CONTINUE READING
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Biochemistry (following paper in this issue)] and also allow comparisons of repressor binding affinities for operator, pseudooperator, and nonoperator DNA

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  • 1981
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Escherichia coli lac repressor-operator system; additional equilibrium measurments on this system

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