Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells.

@article{Golebiewska2008DiffusionCO,
  title={Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells.},
  author={Urszula P. Golebiewska and Marian Nyako and William Woturski and Irina N Zaitseva and Stuart McLaughlin},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 4},
  pages={
          1663-9
        }
}
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls a surprisingly large number of processes in cells. Thus, many investigators have suggested that there might be different pools of PIP(2) on the inner leaflet of the plasma membrane. If a significant fraction of PIP(2) is bound electrostatically to unstructured clusters of basic residues on membrane proteins, the PIP(2) diffusion constant, D, should be reduced. We microinjected micelles of Bodipy TMR-PIP(2) into cells, and we measured D on… CONTINUE READING
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