Diffusion barriers evoked in the rat cortex by reactive astrogliosis.

  title={Diffusion barriers evoked in the rat cortex by reactive astrogliosis.},
  author={Tamara A. Roitbak and Eva Sykov{\'a}},
  volume={28 1},
Changes in extracellular space (ECS) diffusion parameters in astrogliotic tissue around a unilateral cortical stab wound were determined from concentration-time profiles of tetramethylammonium (TMA(+)) using TMA(+)-selective microelectrodes. Three diffusion parameters-ECS volume fraction alpha (alpha = ECS volume/ total tissue volume), tortuosity lambda (lambda(2) = D/ADC; where D is the free and ADC is the apparent diffusion coefficient of TMA(+) in the brain), and nonspecific TMA(+)uptake k… CONTINUE READING


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