Diffusion approximations to the chemical master equation only have a consistent stochastic thermodynamics at chemical equilibrium.

@article{Horowitz2015DiffusionAT,
  title={Diffusion approximations to the chemical master equation only have a consistent stochastic thermodynamics at chemical equilibrium.},
  author={Jordan M. Horowitz},
  journal={The Journal of chemical physics},
  year={2015},
  volume={143 4},
  pages={044111}
}
The stochastic thermodynamics of a dilute, well-stirred mixture of chemically reacting species is built on the stochastic trajectories of reaction events obtained from the chemical master equation. However, when the molecular populations are large, the discrete chemical master equation can be approximated with a continuous diffusion process, like the… CONTINUE READING