Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers.

@article{Oouchi2007DiffusionAM,
  title={Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers.},
  author={Hiroyuki Oouchi and K Yamada and Kazuhiro Sakai and Osamu Kizu and Takao Kubota and Hisao Ito and Tsunehiko Nishimura},
  journal={AJNR. American journal of neuroradiology},
  year={2007},
  volume={28 6},
  pages={1102-6}
}
BACKGROUND AND PURPOSE Voxel size/shape of diffusion tensor imaging (DTI) may directly affect the measurement of fractional anisotropy (FA) in regions where there are crossing fibers. The purpose of this article was to investigate the effect of voxel size/shape on measured FA by using isotropic and nonisotropic voxels. MATERIALS AND METHODS Ten healthy adult volunteers had MR imaging by using a 1.5 T clinical imager. DTI was performed with 2 different voxel sizes: a 2-mm-section isotropic… CONTINUE READING

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