Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons.

@article{Wiegert2007DiffusionAN,
  title={Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons.},
  author={J. Simon Wiegert and C Peter Bengtson and Hilmar Bading},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 40},
  pages={29621-33}
}
The propagation of signals from synapses and dendrites to the nucleus is crucial for long lasting adaptive changes in the nervous system. The ERK-MAPK pathway can link neuronal activity and cell surface receptor activation to the regulation of gene transcription, and it is often considered the principal mediator of synapse-to-nucleus communication in late-phase plasticity and learning. However, the mechanisms underlying ERK1/2 trafficking in dendrites and nuclear translocation in neurons remain… CONTINUE READING
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Bading, unpublished data. ERK1/2 Synapse-to-Nucleus Communication 29632 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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