Diffusion Tensor Imaging Biomarkers for Traumatic Axonal Injury: Analysis of Three Analytic Methods

  title={Diffusion Tensor Imaging Biomarkers for Traumatic Axonal Injury: Analysis of Three Analytic Methods},
  author={Carlos D Marquez de la Plata and Fanpei Gloria Yang and Jun Yi Wang and Kamini Krishnan and Khamid Bakhadirov and Christopher Paliotta and Sina Aslan and Michael D. Devous and Carol Moore and Caryn R. Harper and R. W. Mccoll and C. Munro Cullum and Ramon Diaz-Arrastia},
  journal={Journal of the International Neuropsychological Society},
  pages={24 - 35}
Abstract Traumatic axonal injury (TAI) is a common mechanism of traumatic brain injury not readily identified using conventional neuroimaging modalities. Novel imaging modalities such as diffusion tensor imaging (DTI) can detect microstructural compromise in white matter (WM) in various clinical populations including TAI. DTI-derived data can be analyzed using global methods (i.e., WM histogram or voxel-based approaches) or a regional approach (i.e., tractography). While each of these methods… 
Longitudinal white matter changes after traumatic axonal injury.
Diffusion tensor imaging (DTI) has been useful in showing compromise after traumatic axonal injury (TAI) at the chronic stage; however, white matter (WM) compromise from acute stage of TAI to chronic
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Current Clinical Applications and Future Potential of Diffusion Tensor Imaging in Traumatic Brain Injury
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This study suggests that changes in MD and AD can indicate persisting micro-structure abnormalities in normal-appearing white matter in the brains of subjects with chronic TBI, and suggests that FA in major white matter tracts is correlated with memory in health and in disease, alike.
Longitudinal changes of structural connectivity in traumatic axonal injury
Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome.
Diffusion tensor imaging in moderate-to-severe pediatric traumatic brain injury: changes within an 18 month post-injury interval
The results suggest that TBI-related microstructural changes are dynamic in children and continue until at least 18 months post-injury, consistent with presumed continued degenerative change.


Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury.
FA changes appear to be correlated with injury severity suggesting a role in early diagnosis and prognosis of TBI, possibly reflecting widespread involvement.
Analysis of acute traumatic axonal injury using diffusion tensor imaging
Diffusion tensor imaging may help quantify the overall burden of white matter injury in TBI and provide insights into underlying pathophysiology, and Eigenvalue analysis suggests that the early imaging changes seen in white matter are consistent with axonal swelling rather than axonal truncation.
Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury.
DTI reveals changes in the white matter that are correlated with both acute GCS and Rankin scores at discharge, suggesting DTI may be a valuable biomarker for the severity of tissue injury and a predictor for outcome.
Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging.
The hypothesis that severe TBI is accompanied by diffuse axonal injury is supported, and DTI holds great promise as a diagnostic tool to identify and quantify the degree of white matter injury in TBI patients.
Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study.
Although mean diffusivity and fractional anisotropy abnormalities in these patients with TBI were too subtle to be detected with the whole-brain histogram analysis, they are present in brain areas that are frequent sites of DAI.
Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study.
DTI detected significantly lower trace and elevated FA values in mild TBI subjects compared to controls, which are believed to represent axonal swelling, an early step in the process of axonal injury.
Magnetic resonance imaging of diffuse axonal injury: quantitative assessment of white matter lesion volume.
White matter lesion volume resulting from DAI can be quantitatively and reliably assessed from standard FLAIR-weighted MRIs and whether higher lesion volumes are associated with unfavorable functional outcome 6 months after injury is determined.
Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: a voxel-wise analysis of diffusion tensor imaging.
Multiple foci of low white matter FA and high MD are present in cognitively impaired mild TBI patients, with a distribution that conforms to that of diffuse axonal injury.
Diffusion Tensor Imaging Characteristics of the Corpus Callosum in Mild, Moderate, and Severe Traumatic Brain Injury
Mild TBI is associated with DTI abnormalities in the genu <3 months posttrauma, and DTI suggests a larger contribution of vasogenic edema in thegenu than in the splenium in TBI.