Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review

  title={Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review},
  author={Yaniv Assaf and Ofer Pasternak},
  journal={Journal of Molecular Neuroscience},
Diffusion tensor imaging (DTI) has become one of the most popular MRI techniques in brain research, as well as in clinical practice. The number of brain studies with DTI is growing steadily and, over the last decade, has produced more than 700 publications. Diffusion tensor imaging enables visualization and characterization of white matter fascicli in two and three dimensions. Since the introduction of this methodology in 1994, it has been used to study the white matter architecture and… 
Diffusion Tensor Imaging (DTI) and Tractography
This chapter tries to give an introduction to the mechanisms of Diffusion Tensor Imaging and will work to explain its utilization while highlighting limitations of diffusivity parameters as well as examples of its successful applications.
A systematic bias in DTI findings
It is shown that unincorporated anisotropic free water in perivascular space (PVS) significantly, and systematically, biases DTI measures, casting new light on the biological validity of many previously reported findings.
Diffusion Tensor Imaging Investigations of Mild Brain Damage
These findings provide preliminary proof of principal evidence that DTI can be used to diagnose mTBI in individual cases and degree of hemispheric asymmetry may be a useful biomarker for detecting subtle white matter changes.
Diffusion tensor imaging provides new clues in adults with ADHD (Commentary on Konrad et al.)
The novel findings of DTI abnormalities in the inferior frontoccipital fasciculus highlight the role of the orbitofrontal cortex in adult ADHD, complementing previous anatomic results and suggesting fewer crossing fibers in the patients with ADHD.
Advantages of Multi-shell Diffusion for Studies of Brain Development in Youth
The results reveal that multi-shell diffusion imaging sequences can be leveraged to robustly characterize neurodevelopment, even within the framework of DTI, and suggest that while traditional DTI is sensitive to neurodevelopmental trends, contemporary modeling techniques confer key advantages for neuro developmental inquiries.
Diffusion tensor imaging in the study of language and aphasia
Background: Diffusion tensor imaging (DTI) is an emerging research technique that is used to map and characterise white matter tracts in the healthy and damaged brain. Aims: The aim of this paper is
In vivo diffusion tensor magnetic resonance imaging and fiber tracking of the mouse brain
High resolution images of rotational invariant parameters of the diffusion tensor, such as fractional anisotropy, volume ratio or main eigenvalues allowed quantitative comparisons in‐between regions of interest (ROIs) and showed significant differences between various white matter regions.
[Comparison of diffusion tensor imaging-derived fractional anisotropy in multiple centers for identical human subjects].
Assessment of inter-center variability of fractional anisotropy in DTI with multiple motion probing gradients indicates that the FA value was affected by the MPG-schema as well as by the MPG-directions.
Multi-parametric quantification of white matter microstructure in the human brain
To date the majority of MRI studies of white matter (WM) microstructure have used diffusion tensor MRI (DT-MRI), comparing groups on a voxel-by-voxel basis. There are limitations to this approach.


Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis
DTI detects diffuse abnormalities in the normal-appearing white matter of MS patients, and the findings in lesions appear to relate to pathologic severity, and its use in serial studies and in larger clinical cohorts may increase the understanding of pathogenetic mechanisms of reversible and persistent disability.
Diffusion Tensor Magnetic Resonance Imaging in Multiple Sclerosis
Diffusionweighted imaging (DWI) provides information about water diffusion in tissue and diffusion tensor MRI (DT‐MRI) about fiber direction, allowing for the identification of WMabnormalities that are not apparent on conventional MRI images.
MRI Atlas of Human White Matter
MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging, which offers a full segmentation of 220 white-matter and gray-matter structures with boundaries.
Diffusion tensor imaging in schizophrenia
Diffusion tensor MR imaging of the human brain.
A quantitative characterization of water diffusion in anisotropic, heterogeneously oriented tissues is clinically feasible and should improve the neuroradiologic assessment of a variety of gray and white matter disorders.
A review of diffusion tensor imaging studies in schizophrenia.
Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging.
Changes in magnitude and anisotropy of water diffusion follow stereotypical time courses during brain development that can be empirically described with multiexponential regression models, which suggests that quantitative scalar parameters derived from diffusion-tensor MR imaging may provide clinically useful developmental milestones for brain maturity.
Study of the effect of CSF suppression on white matter diffusion anisotropy mapping of healthy human brain
FLAIR DTI suppresses the CSF signal that otherwise masks underlying anisotropic parenchymal tissue through partial volume averaging, and was detectable qualitatively and verified quantitatively by analyses of the relative anisotropy (RA) distribution over white matter structures for 11 subjects.
High b‐value q‐space analyzed diffusion‐weighted MRI: Application to multiple sclerosis
The potential diagnostic capacity of high b‐value diffusion q‐space analyzed MR images is discussed, and experimental data that explains the consequences of using the q‐ space approach once the short pulse gradient approximation is violated are presented.
Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance and diffusion-tensor imaging.
The combination of DT and fMR imaging for presurgical functional brain mapping provides valuable information that cannot be extracted using either method alone and could be improved by considering results obtained with both methods.