Diffusing substances during spreading depolarization: analytical expressions for propagation speed, triggering, and concentration time courses.

Spreading depolarization (SD) is an important phenomenon in stroke and migraine. However, the processes underlying the propagation of SD are still poorly understood, and an elementary model that is both physiological and quantitative is lacking. We show that, during the onset and propagation of SD, the concentration time courses of excitatory substances… CONTINUE READING