• DOI:10.1136/THX.52.9.796
Corpus ID: 31914210

Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins.

@article{Mitchell1997DiffusibleCF,
  title={Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins.},
  author={C. Mitchell and J. Slight and K. Donaldson},
  journal={Thorax},
  year={1997},
  volume={52 9},
  pages={
          796-801
        }
}

C. Mitchell, J. Slight, K. Donaldson

Published 1997

Biology, Medicine

Thorax

BACKGROUND The fungus Aspergillus fumigatus, whose spores are present ubiquitously in the air, causes a range of diseases in the human lung. A small molecular weight (< 10 kD) heat stable toxin released from the spores of clinical and environmental isolates of A fumigatus within minutes of deposition in aqueous solution has previously been described. A key effect of the toxin was to inhibit the oxidative burst of macrophages as measured by superoxide anion release. It was hypothesised that the… CONTINUE READING

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