Diffuse panbronchiolitis in East Asia

@article{Azuma2006DiffusePI,
  title={Diffuse panbronchiolitis in East Asia},
  author={Arata Azuma and Shoji Kudoh},
  journal={Respirology},
  year={2006},
  volume={11}
}
Abstract:  Diffuse panbronchiolitis is characterized by chronic sinobronchial infection and diffuse bilateral centrilobular lesions consisting of peribronchial infiltration of inflammatory cells. At present, it is known that diffuse panbronchiolitis is relatively restricted to East Asia. This uneven distribution is suspected to be highly associated with genetic predisposition located between human leucocyte antigen‐A and ‐B loci. Low‐dose, long‐term macrolide therapy for the disease was… 

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References

SHOWING 1-10 OF 118 REFERENCES

Diffuse panbronchiolitis: histologic diagnosis in unsuspected cases involving North American residents of Asian descent.

The immigration of Asians and sporadic case reports involving non-Asians make recognition of this disease entity important, as the implications for therapy are different than that of other small airway diseases.

Diffuse panbronchiolitis. A disease of the transitional zone of the lung.

Diffuse panbronchiolitis belongs to a distinctly different category from these diseases, and should be distinguished from them, because it may often show rapid progression with fatal outcome.

Clinical profiles of Chinese patients with diffuse panbronchiolitis

The only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles are reported and should help other clinicians in the investigation and management of DPB in non- Japanese patients.

Diffuse panbronchiolitis, the first case reports in Thailand.

Diffuse panbronchiolitis should be suspected in patients who have clinical manifestations of chronic cough, productive sputum and shortness of breath and chronic treatment with low-dose erythromycin can improve the survival of patients.

Diffuse panbronchiolitis in an Asian immigrant.

The known efficacy of low dose erythromycin in DPB was again confirmed after failure of long term high dose corticosteroid therapy administered before an accurate diagnosis had been made.

Analysis of HLA antigens in patients with diffuse panbronchiolitis.

HLA analysis of patients with diffuse panbronchiolitis found that Bw54, or its related haplotype, exists only in Japanese, Chinese, and Korean populations, which suggests that one or some of the genes controlling the susceptibility and/or immune responsiveness of diffusePanbronChiolitis might be located near HLA loci.

The first report of diffuse panbronchiolitis in Korea: five case reports.

In three clinically and radiologically suspected cases, high resolution computed tomography showed the typical findings of DPB and other diseases such as pulmonary emphysema, bronchial asthma, chronic bronchitis and bronchiectasis could be ruled out.

Diffuse panbronchiolitis in Latin America.

The present case shows that DPB, although rare in Western countries, is not a disease restricted to Asia, and always should be considered in the differential diagnosis of nodular radiographic opacities associated with airflow limitation, especially in non-smokers with a history of chronic sinusitis.

A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis.

The number of neutrophils in the peripheral blood was not affected by erythromycin, indicating that the drug was not toxic, and there was a significant correlation between the reduction of NCA and neutrophil percentage in pre- and post-eryhromycin treatment BALF.
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