Diffuse malformations of cortical development.

  title={Diffuse malformations of cortical development.},
  author={Nadia Bahi-Buisson and Renzo Guerrini},
  journal={Handbook of clinical neurology},
Malformations of cortical development (MCD) represent a major cause of developmental disabilities and severe epilepsy. Advances in imaging and genetics have improved the diagnosis and classification of these conditions. Up to now, eight genes have been involved in different types of MCD. Lissencephaly-pachygyria and subcortical band heterotopia (SBH) represent a malformative spectrum resulting from mutations of either LIS1 or DCX genes. LIS1 mutations cause a more severe malformation in the… CONTINUE READING