Diffuse large B-cell non-Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome.

@article{Boulanger2001DiffuseLB,
  title={Diffuse large B-cell non-Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome.},
  author={Emmanuelle Boulanger and Fr{\'e}d{\'e}ric Rieux-Laucat and Christophe Picard and M. A. Legall and François Sigaux and J. P. Clauvel and Eric Oksenhendler and Françoise le Deist and V{\'e}ronique Meignin},
  journal={British journal of haematology},
  year={2001},
  volume={113 2},
  pages={432-4}
}
Mutations of Fas or Fas ligand genes result in the autoimmune lymphoproliferative syndrome (ALPS) in humans. We report here a diffuse large B-cell non-Hodgkin's lymphoma occurring in a man with ALPS. Fas-mediated lymphocyte apoptosis was defective in vitro, owing to a mutation within the death domain of the Fas molecule. High-dose methotrexate and… CONTINUE READING