Diffuse glomerulosclerosis without tubular injury does not directly manifest renal dysfunction in nephrotic mice (ICGN strain).

@article{Mizuno1997DiffuseGW,
  title={Diffuse glomerulosclerosis without tubular injury does not directly manifest renal dysfunction in nephrotic mice (ICGN strain).},
  author={Shinya Mizuno and Bing Yue and Masahiko Okamoto and Youhei Horikawa and Tsutomu Miki Kurosawa},
  journal={Experimental nephrology},
  year={1997},
  volume={5 6},
  pages={
          498-507
        }
}
Chronic renal disease is characterized by pathological conditions, caused by a progressive and irreversible loss of renal function. The nephrotic mouse (ICGN strain) is a useful model for demonstrating progressive nephrotic syndrome (NS). In the present study, we examined the natural course of kidney disease shown by the NS mice, aging 6-26 weeks, in order to characterize their pathological conditions. Urine and serum biochemistry revealed that massive albuminuria and hypoalbuminemia were… CONTINUE READING

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