Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy.

@article{Tanaka2016DiffuseFL,
  title={Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy.},
  author={Yasuaki Tanaka and Dolkun Rahmutula and Srikant K Duggirala and Babak Nazer and Qizhi Fang and Jeffrey E. Olgin and Richard E. Sievers and Edward P Gerstenfeld},
  journal={Heart rhythm},
  year={2016},
  volume={13 2},
  pages={547-54}
}
BACKGROUND Frequent premature ventricular contractions (PVCs) may lead to dilated cardiomyopathy. A leftward shift in the unipolar voltage distribution in patients with cardiomyopathy has also been described and attributed to increased fibrosis. OBJECTIVES We established a swine model of PVC-induced cardiomyopathy and assessed (1) whether an increase in left ventricular fibrosis occurs and (2) whether increased fibrosis leads to a leftward shift in the unipolar voltage distribution. METHODS… CONTINUE READING

Similar Papers

Loading similar papers…