Diffuse central nervous system protoplasmic astrocytoma.


Protoplasmic astrocytoma is an extremely rare form of grade II low grade glioma which usually presents as a discrete mass lesion. We describe a 3-year-old female with diffuse protoplasmic astrocytoma with parenchymal involvement and leptomeningeal spread. This tumour proved extremely difficult to diagnose and followed a progressive course. Three superficial biopsies did not give the diagnosis and this was only confirmed 8 months from presentation from a larger fourth biopsy taken deeper from the cerebellum. To our knowledge this case represents the distinct presentation of protoplasmic astrocytoma presenting as extensive diffuse meningeal disease.

DOI: 10.1002/pbc.22402


Citations per Year

315 Citations

Semantic Scholar estimates that this publication has 315 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Manley2010DiffuseCN, title={Diffuse central nervous system protoplasmic astrocytoma.}, author={Sue E Manley and Daniel A. Crooks and Libby Artingstall and Neil Buxton and Richard E. Appleton and Andrew I Riordan and Gavin A Cleary and Barry L. Pizer}, journal={Pediatric blood & cancer}, year={2010}, volume={54 5}, pages={768-9} }