Diffuse brain injury induces local expression of Na+/myo-inositol cotransporter in the rat brain.

@article{Ueda2001DiffuseBI,
  title={Diffuse brain injury induces local expression of Na+/myo-inositol cotransporter in the rat brain.},
  author={Takashi Ueda and Akira Iwata and Hirokazu Komatsu and Noritaka Aihara and Kiyofumi Yamada and Shinya Ugawa and Shoichi Shimada},
  journal={Brain research. Molecular brain research},
  year={2001},
  volume={86 1-2},
  pages={
          63-9
        }
}
We studied expression of an osmoprotective gene, sodium/myo-inositol cotransporter (SMIT) in Marmarou's animal model for human diffuse brain injury by in situ hybridization and immunohistochemistry. In rats with diffuse brain injury, transient upregulation of SMIT mRNA was exclusively observed in the lateral area of pyramidal tract in lower brainstem. The expression was induced at 1 h after injury, peaked at 24 h, and returned to almost control levels at 48 h. Upregulated expression was found… CONTINUE READING